Of chemokines and their receptors in the pathogenesis of systemic lupus erythematosus New Progress in Research.doc

 PAGE \* MERGEFORMAT 25 Of chemokines and their receptors in the pathogenesis of systemic lupus erythematosus New Progress in Research Keywords: Systemic lupus erythematosus chemokine Chemokine (chemokine) is a kind of a similar structure, the main pairs of white blood cells with a chemotactic role in a variety of biological effects of small molecule protein in the body’s defense and inflammatory reactions plays an important regulatory role. In recent years, with the bioinformatics and the development of basic information, it was discovered that a number of new chemokines and their receptors, in particular chemokine receptors were found to act as a coreceptor HIV infection after [1], chemotaxis factor field has attracted people’s attention. So far, has been found that about 50 kinds of human chemokine [2], which has the following biological activity: (1) on various cell chemotactic activity; (2) activates the immune activity of cells and involved in inflammation, immune regulation; (3) anti-bacterial and resist allergens and other functions; (4) Hematopoietic cell regulation; (5) involved in cell growth, metabolism and apoptosis; (6) participate in vascular repair and regeneration; (7) in tumor immunity and its play an important role in the transfer of [3] This paper focuses on chemokines and their receptors in systemic lupus erythematosus (SLE) the role of the occurrence and development are reviewed. Systemic lupus erythematosus (SLE) is a kind of autoantibody production and immune complex formation is characterized by autoimmune diseases, autoantibodies and immune complexes (immune complexes, ICs) deposition can cause multiple organ inflammation and injury , tissue damage and dysfunction, primarily through the deposition of immune complexes and a variety of activities arising from the direct effect of media. Involve a variety of inflammatory mediators and the complex interactions between cells. One of the specific leukocyte chemokine chem