Octreotide in the treatment of acute upper gastrointestinal bleeding in clinical observation.doc

 PAGE \* MERGEFORMAT 3 Octreotide in the treatment of acute upper gastrointestinal bleeding in clinical observation [Keywords:] Octreotide in acute upper gastrointestinal bleeding Octreotide is a synthetic long-acting inhibition of growth hormone releasing hormone analogue for the eight-peptide [1], can inhibit a variety of digestive juice and digestive hormone secretion, reducing blood flow and reduce visceral portal pressure [2 ]. Acute upper gastrointestinal bleeding is a common emergency medicine, one of [3], because of more complications, a high fatality rate, if not promptly and effectively control the bleeding, often in patients with life-threatening [4]. In the earlier bleeding has an important clinical significance. Octreotide for the treatment of acute upper gastrointestinal bleeding, has achieved satisfactory outcome. Undergraduate since January 2006 to June 2008 of the 72 treated patients with acute upper gastrointestinal bleeding were observed in patients with the following results. A clinical data 1.1 General information on 72 cases of acute upper gastrointestinal bleeding in patients, including 40 cases of male and female 32 cases; aged 16 to 82 years. Unexpected hematemesis (or coffee-like material) and / or there will be black, are accompanied by bleeding the performance of peripheral circulatory failure: dizziness, fatigue, low blood pressure, pulse speed, Hb drop and so on. Gastroscopy: 8 cases of bleeding esophageal varices, portal hypertensive gastric mucosal lesions in 5 cases, gastric ulcer with hemorrhage in 20 cases, duodenal ulcer with active bleeding in 31 cases, 8 cases of acute gastric mucosal lesions. Were randomly divided into treatment group (A group) and control group (B group). 1.2 Treatment A group of octreotide 0.1mg slow intravenous injection of 20 ml normal saline, followed by 0.1 mg octreotide in 5% glucose in 250 ml to 25 μ g / h slow intravenous infusion, ≥ 48 ~ 72 h, while pantoprazole zole 40 mg in 100 ml normal