Patients with acute pulmonary thromboembolism system function in coagulation and fibrinolysis research.doc

 PAGE \* MERGEFORMAT 11 Patients with acute pulmonary thromboembolism system function in coagulation and fibrinolysis research Of: Zhang Jin Yang, Zhang Hong Xia Zhou Wei Li Xiuzhong [Abstract] of acute pulmonary thromboembolism (acute PTE) part of coagulation and fibrinolysis system in patients with anticoagulant, procoagulant factors and its clinical significance. Methods selected 60 patients with acute PTE patients, of which a large area of acute PTE 10 cases, non- large area of #8203;#8203;acute PTE 50 cases, 40 normal subjects (control group), the use of coagulation test for quantitative detection method for the determination of plasma protein group C (PC), plasma protein S (PS) activity, using enzyme-linked immunosorbent assay (ELISA) Determination of thrombomodulin (TM). the results of PC, PS activity: acute massive acute PTE were (69.5 + -21.7)%, (69.1 + -14.4)%, non-large group (93.1 + -18.8)% , (83.3 + -18.9)%, significantly lower than the control group (105.5 + -27.7)%, (112.4 + -28.6)% (P all lt;0.01), large group of PC, PS activity was significantly lower than large group (PC: P lt;0.01, PS: P lt;0.05). TM content: acute massive pulmonary embolism group were (19.7 + -10.2) ng / mL, non-large group (16.6 + -10.0) ng / mL, were significantly higher than the control group (7.5 + -4.3) ng / mL (P lt;0.01), a large area and non-large-scale no significant difference. case group PC, PS-positive rate was 20.0% , 26.7%, significantly higher than the control group, 5%, 5% (P lt;0.05), odds ratio (OR) and 95% confidence intervals were 4.75 (1.16-19.3), 6.9 (1.75-27.2). Conclusion Plasma PC, PS activity to reduce prone to pulmonary embolism, PC, PS activity and embolization to reduce the severity of the degree of positive correlation between plasma TM levels were significantly higher, suggesting various causes of pulmonary vascular endothelial injury is a risk factor for occurrence of PTE. [Keywords:] pulmonary embolism Protein C Protein S thrombomodu