Pinellia system activity and inhibition of matrix metalloproteinase-experimental study of anti-tumor mechanism.docVIP

 PAGE \* MERGEFORMAT 11 Pinellia system activity and inhibition of matrix metalloproteinase-experimental study of anti-tumor mechanism Author: Ge Wang Yan Yang Jingang room school hearing Zhao Shuhua Li Tian [Abstract] Objective To study the system of Pinellia pairs of matrix metalloproteinase -16 (MMP-16) activity in vivo. Methods According to inhibit MMPs activity of the substrate degradation rate after the reduction principle, by detecting the substrate degradation rate, measured on traditional Chinese medicine system of Pinellia MMP-16 in vivo. The results with the blank control group and positive control group, the system Pinellia has a strong activity in inhibiting MMP-16 roles, its inhibitory activity IC50 = 23 μ g / ml. Conclusion Pinellia decoction can inhibit in vitro the role of MMP-16 activity, its inhibitory activity stronger, and a dose-dependent manner. [Keywords:] system of Pinellia ternata; matrix metalloproteinase; activity analysis; anti-tumor Abstract: ObjectiveTo study the inhibitory action of pinelliae tuber on matrix metalloproteinase-16 (MMP-16). MethodsThe decreasing of the degrade rate of substrate is associated with the inhibition of matrix metalloproteinase-16. We studied the inhibitory activity of pinelliae tuber on MMP by observing the degrade rate of substrate. ResultsPinelliae tuber strongly inhibited the activity of MMP-16, and the IC50 was 23 μ g / ml.ConclusionThe apozem of pinelliae tuber has inhibitory activity on MMP-16 in a dose-dependent manner in vivo. Keywords:: Pinelliae tuber; Matrix metalloproteinase; Methods for the analysis of enzymatic activity China’s traditional Chinese medicine Pinellia Pinelliae tuber with phlegm dampness, Jiangni vomiting, Xiaopi Sanjie effect. The long-term clinical practice shows that a precise effect of Pinellia. Health products Banxia small drugs, the clinical oral administration must go through processing or compatibility with the ginger to reduce the toxicity, so in this experim