Plasma homocysteine and its related enzyme gene polymorphism and the relationship between Alzheimer disease.doc

 PAGE \* MERGEFORMAT 11 Plasma homocysteine and its related enzyme gene polymorphism and the relationship between Alzheimer disease Of: Zhang Shenglin, SPECTROSCOPY, Yang Xiaojuan [Abstract] Objective To investigate the homocysteine #8203;#8203;(homocysteine, Hcy and its related enzyme 5,10 methylenetetrahydrofolate reductase (methylenetetrahydrofolate reductase, MTHFR gene polymorphism and Alzheimer’s disease (Alzheimer’s disease, AD relationship. Methods 68 cases 68 cases of AD patients and healthy control group were treated with plasma Hcy levels of circulating enzyme, polymerase chain reaction - restriction fragment length polymorphism (PCR-RFLP method for detection of MTHFR C677T polymorphism. Results Plasma Hcy levels of AD patients 13.92 +-5.513mol / L was significantly higher than the control group 10.83 +-3.800mol / L, MTHFR C677T genotypes in the overall distribution of the difference between the two groups was significant, in which C / T genotype proportion of AD group (64.71% was significantly higher (42.65%. Conclusions The plasma Hcy levels may be involved in the high incidence of the development of AD, MTHFR gene mutation C677T gene polymorphism may be involved in the genetic mechanism of AD, Shanxi Han Plasma Hcy levels were high, largely genetic to some extent. [Keywords:] Alzheimer Disease, Homocysteine, 5,10 methylenetetrahydrofolate reductase gene mutation [Abstract] Objective To research the relationship of homocysteine #8203;#8203;(Hcy and gene polymorphisms of its related enzyme (Methylene tetrahydrofolate reductase, MTHFR with Alzheimer’s disease (AD in Han people of Shanxi Province.Methods The plasma Hcy level was measured by means of cyclophorase and the polymorphism of MTHFR C677T was analyzed by polymerase chain reaction-restrictive fragment length polymorphism (PCR-RFLP in 68 patients with AD and 68 healthy controls.Results The plasma Hcy level of AD group (13.92 + -5.513 umol / L was significantly higher than that (10.