Potassium ion channels in different gestational age the role of contraction of rat ductus arteriosus.docVIP

 PAGE \* MERGEFORMAT 10 Potassium ion channels in different gestational age the role of contraction of rat ductus arteriosus [Abstract] Objective To study the effect of patent ductus arteriosus smooth muscle in the adenosine triphosphate (ATP)-sensitive potassium channels (KATP) and voltage-dependent potassium channels (Kv) and its developmental changes of arterial contraction in the role. Method by measuring the gestational age of 19 days (premature) and 21 days (term) (n = 8) fetal arterial vascular ring tension and the use of whole-cell patch-clamp technique methods to measure arterial smooth muscle cells of a single potassium ion currents, observation KATP agonist imidacloprid La to Er and the KATP blocker glibenclamide, Kv blocker, 4 - aminopyridine on arterial contraction and potassium ion currents. The results can be contracted glibenclamide 21 days gestational age fetal rat arterial catheter, but 19 days of no effect. Potassium current can increase due to imidacloprid pull in Seoul due to glyburide decreased, but this reduction in the gestational age of the current 21-day patent ductus arteriosus was significantly greater than 19 days. 4 - aminopyridine role in the two groups no significant difference. Conclusion This study data suggest that in preterm children compared with full-term children, the total Kv current was no significant difference, but the KATP current is significantly reduced, KATP channels are not mature in support of KATP in the arterial smooth muscle as an oxygen receptor, patent ductus arteriosus in premature children has not closed the high incidence of one of the reasons. [Keywords:] patent ductus arteriosus; oxygen; potassium ion channel; preterm children The role of potassium channels in oxygen-induced contraction of ductus arteriosus in fetal rat of different gestation age [Abstract] Objective To investigated the role of ATP sensitive potassium channel and voltage-dependent potassium channel in oxygen-induced contract