Preparation of anti-epileptic medicine illegally added chemical analysis of drug-related problems and countermeasures.doc

 PAGE \* MERGEFORMAT 17 Preparation of anti-epileptic medicine illegally added chemical analysis of drug-related problems and countermeasures [Keywords:] traditional Chinese medicine preparations of anti-epileptic drugs illegally added chemical Traditional Chinese medicine for the treatment of pediatric epilepsy in the country has a long history and a certain effect. However, in recent years, we have found an increasing number of unscrupulous traders in order to gain competitive pharmaceutical market, the name of ‘pure Chinese anti-epileptic’ banner, without going through any pharmaco-toxicological experiment, based on traditional Chinese medicine preparations without authorization chemical illegally added anti-epileptic drugs. This phenomenon seriously affect the safety of drug use in children with epilepsy and therapeutic effect, should arouse the attention and thinking the whole society. Here, the author of the status quo on this issue, the causes of hazards are discussed below, and put forward corresponding countermeasures. A literature review In recent years, traditional Chinese medicine preparations on anti-epilepsy medicine ingredients illegal to add the event to be reported. Wang et al [1] In the three years between 1997 and 2001 successively detected by TDM in children taking the ‘pure herbal anti-epileptic drugs’ containing western drug ingredients up to 45 cases of epilepsy, and some have reached a toxic blood concentration; Kan well, etc. [2] measured by fluorescence polarization immunoassay serving only 40 cases of epilepsy in traditional Chinese medicine in patients with valproic acid (VPA), carbamazepine (CBZ), phenobarbital (PB), phenytoin (PHT) exist in the type and the concentration found in the blood of all patients were measured in a 1 ~ 4 kinds of chemicals; Zou et al [3] of 30 patients taking 23 kinds of proprietary Chinese medicines after antiepileptic antiepileptic blood concentration of western medicine, were found in with Western d