Procalcitonin in Respiratory Diseases.doc

 PAGE \* MERGEFORMAT 6 Procalcitonin in Respiratory Diseases [Abstract] Calcitonin was originally a calcitonin precursor hormone, normally secreted by the thyroid C cells by intracellular proteolytic enzymes formed after hydrolysis of the active ingredient. Healthy human serum PCT were very low. The study found, PCT in a number of bacterial infection diseases increased, but the virus infection and non-specific inflammatory diseases to maintain a low level, suggesting that elevated levels of serum PCT and bacterial infection. Procalcitonin in many clinical field has been applied. In this paper, procalcitonin in respiratory diseases in the application of new advances are reviewed. [Keywords:] procalcitonin; bacterial infection; respiratory system Procalcitonin (procalcitonin, PCT) in recent years are gradually attention, it was believed there is a systemic inflammatory reaction an important indicator of serious bacterial infections [1]. Calcitonin Calcitonin was originally the first peptide, in normal circumstances, PCT by the thyroid C-cells. In healthy human blood, PCT can not be tested to the (amp;lt;0.1ng/ml), in severe infections (such as bacteria, parasites and fungal infections) and a systemic performance, PCT levels can be elevated, and some can exceed 100ng / ml, then the majority of PCT produced by organizations outside the thyroid gland. Procalcitonin in many clinical field has been applied: it is used in the identification of bacterial meningitis and viral meningitis [2], major surgery and severe trauma patients with complications in the monitoring of bacterial infections [3,4], autoimmune disease and cancer surveillance in patients with bacterial infectious complications [5,6], edema, aseptic necrosis and infection in the differential diagnosis of necrotizing pancreatitis [7], organ transplant rejection and infection complications in the differential diagnosis [8 ], bacterial infection systemic inflammatory response syndrome (SIRS) supporting