Progress in lithium salt Monitoring Methods.doc

 PAGE \* MERGEFORMAT 11 Progress in lithium salt Monitoring Methods Author: Guo Xin-Sheng Wang Zhimin, Zhu Xia [Keywords:] lithium carbonate; concentration monitoring; new progress 1949 Australian psychiatrist Cade accidental discovery of lithium treatment of bipolar affective disorder role in creating a miracle in the history of psychiatric treatment. Lithium salt in 1970, was FDA approved drug for the treatment of manic depression. Is not due to lithium salt and protein binding, clearance via a single (through renal excretion), serum lithium concentration range of small (0.4 mmol ~ 1.5 mmol * L-1), almost all cases the concentration of 2.0 mmol * L  1 when adverse reactions. Are reported in the literature [1,2] Treatment of lithium salt of the minimum toxic concentration of 1.6 mmol * L-1, combined treatment of different drugs, and other factors can affect the patient’s blood lithium concentration, its side effects, toxicity occur. Professionals to improve awareness of blood lithium concentration monitoring, regular monitoring of serum lithium concentrations are measured on a variety of methods of research are summarized below. A flame photometric detection Blood lithium concentration Nevirus first reported by modification of flame photometer, using flame spectrometry lithium salt [3]. The detection limit 0.02 mmol * L-1, recovery of 95%, variation (1.0 ± 0.02) mmol * L-1; Na at 120 mmol ~ 160 mmol * L-1, K 2 mmol ~ 8 mmol * L-1 does not affect the reproducibility and recovery of other metal ions such as Ca2, Mg2, Cu2, Zn2, Fe3, Al3, etc. within 5% of its impact. And the reference method error of 0.7% compared to [4]. Since the method does not require special expensive equipment, since the domestic part of the hospital still in use. 2 Atomic Absorption Spectrometry Bowman first reported in 1967 by the use of atomic absorption spectrometry and serum lithium concentrations [5], flame atomic absorption and non-flame atomic absorption spectrome