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Psoralen Tang on dementia hippocampus NR2B BDNF - TrkB expression.doc

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Psoralen Tang on dementia hippocampus NR2B BDNF - TrkB expression

Psoralen Tang on dementia hippocampus NR2B BDNF / TrkB expression Of: in the Xiang Cheng, Cui Zhiyuan, JOURNAL OF INTEGRATED TRADITIONAL onto information [Abstract] Objective To investigate the psoralen decoction on vascular dementia to improve spatial learning and memory mechanism. Methods repeated infusion of bilateral carotid artery ligation, rats with the Morris test spatial learning and memory tests, RT-PCR Determination closely related to learning and memory in NR2B, BDNF / TrkB gene product. Results psoralen soup high and low dose group were significantly shorter escape latency in the model group (P lt;0.01, psoralen soup high and low doses, can significantly increased NR2B, BDNF / TrkBmRNA expression (P lt;0.05. Conclusion psoralen soup can improve vascular dementia rats spatial memory, and its possible mechanism is by increasing NR2B, BDNF / TrkBmRNA expression levels play a role. [Keywords:] psoralen soup, vascular dementia, NR2B, BDNF / TrkBmRNA Abstract: ObjectiveTo elucidate the mechanism of BuGuZhi Decoction how to improve vascular dementia rats on spatial learning and memory.MethodsExperimental VD model rats were subjected to the bilateral common carotid arteries ligation and reperfusion, the performance of spatial learning and memory of all rats were measured using the Morris Water Maze.We studied the level of NR2B, BDNF / TrkB mRNAs in the hippocampus of rats by RT-PCR technique. ResultsBuGuZhi Decoction could significantly shorten the escape latency time in place navigation test, increase the number of passing through primary flat place in spatial probe test (P lt;0.01. The level of NR2B, BDNF / TrkB mRNAs in the BuGuZhi Decoction group were markedly higher than those of the model group and the sham operation group (P lt;0.05 or P lt;0.01). ConclusionBuGuZhi Decoction can improve the spacious learning-memory.The mechanism may enhance the expression level of NR2B, BDNF / TrkB mRNAs. Keywords:: BuGuzhi Decoction; Vascular dementia; N