Progress related to adiponectin.docVIP

 PAGE \* MERGEFORMAT 11 Progress related to adiponectin [Keywords:] adiponectin, diabetes mellitus, type 2, cardiovascular disease, cerebrovascular disorders Release of adipose tissue fat storage and not just a place, but also a tissue with endocrine function. Adiponectin by adipose tissue is considered the expression and secretion of insulin resistance in a variety of products in the closest relationship with a specific cell factor. At present a large number of studies have confirmed that adiponectin involved in insulin resistance, in clinical and obesity, insulin resistance, type 2 diabetes and cardiovascular disease are closely related [1]. the author of adiponectin on Research Development as follows. A source of adiponectin and structure In 1995, Scherer et al [2] First of all the fat cells from rat isolated a new gene, its encoded protein named Acrp30 (adipocyte complement related protein of 30kD.1999 of Arita et al [3] named it adiponectin factors, and the establishment of human plasma can be determined apM1 product concentrations. human adiponectin by the 244 amino acids, including four functional areas: the secretion of amino-terminal signal sequence (18 amino acid signal peptide, a short non- helix, a composition of 22 Glyxy repeats, carboxyl-terminal globular functional areas. circulating adiponectin closely homologous to 3 polymer form, disulfide linked to each other, and further formation of polymer 9 or 12 mer [4]. 2 of adiponectin and obesity Many studies indicate that obesity in the lower level of plasma adiponectin. Some studies [5] found that the blood is rich in healthy volunteers adiponectin and obesity in plasma adiponectin concentration was significantly lower than non-obese. There of display [6], plasma adiponectin concentration and body mass index changes (BMI), waist to hip ratio (WHR), body fat percentage were negatively correlated. multiple linear regression model, adjusted BMI and waist circumference, plasma adip