Purification of guinea pig inner ear tissue antigens induced experimental autoimmune Menieres disease study.doc
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Purification of guinea pig inner ear tissue antigens induced experimental autoimmune Menieres disease study
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Purification of guinea pig inner ear tissue antigens induced experimental autoimmune Meniere’s disease study
Of: Li Yujin, Tan Changjiang, yellow and, Cai Wenjun, Li cream
[Abstract] Objective: To study the purification of the inner ear antigen 4 immune inner ear disease caused by Meniere’s disease-like situation, to understand the pathogenicity of the antigen, and specifically its distribution in the inner ear. METHODS: 70 guinea pigs were randomly divided into A, B, C, D, E 5 group (A group of 10 mice, 15 rats in each group more than 4 to guinea pig inner ear tissue antigens of the 4 sub-fractions (relative molecular mass of the order of 28 000,42 000,58 000 and 68 000 as the antigen, followed by immune B, C, D and E group of guinea pigs to observe the auditory function, vestibular function, serum specific antibody levels and changes in inner ear morphology, and immunohistochemistry was used to determine the distribution in the cochlea and expression. Results: before and after immunization A (control, B group, the average hearing threshold was no significant difference in the inner ear is also no obvious pathological changes. immunized B, C, D, E specific antibody levels in serum were significantly increased. Group B immunized animals not found hearing loss, C Group 3 animals (4 ears, D Group 4 animals (6 ears, E Group 4 animals (6 ears hearing loss occurs, some hearing loss and endolymphatic hydrops ear emergence spiral ganglion cells decreased. Immunohistochemically, 68 000 protein antibody mainly distributed in the stria vascularis, Corti device also has a small amount of the distribution of 28 000 protein antibody is mainly distributed in the spiral ganglion, 42 000 and 58 000 proteins in the spiral ganglion, vascular pattern and the spiral ligament are distributed. Conclusion: crude inner ear antigens in 000 and 68 000 42 000,58 subfractions can independently induce autoimmune inner ear disease like Meniere’s disease, experi
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