Pyridine calcium channel mRNA expression in mice of Hai Paxi.doc

 PAGE \* MERGEFORMAT 10 Pyridine calcium channel mRNA expression in mice of Hai Paxi Of: GUO Xiao-Qiang Xiaowei Fu Yong Yao Qingguo [Abstract] Objective To study the expression of calcium in the regulation of pyridine Hai Paxi. Methods Kunming mice were divided into 4 groups were injected isotonic NaCl, MgCl2, CaCl2 and FeCl3 solution, collecting serum and liver tissue, serum iron and total iron binding capacity using the kit, the liver mRNA levels Hai Paxi ? use semi-quantitative RT PCR identified. Results and sodium compared to calcium can reduce serum iron levels (P lt;0.05, while inhibiting Hai Paxi Popular mRNA expression (P lt;0.05. Conclusion calcium can regulate the expression of mRNA Hai Paxi pyridine iron metabolism. [Keywords:] of calcium ion, Hai Paxi pyridine, iron metabolism Iron is necessary for body growth and development of trace elements in biological oxidation and biological processes such as DNA replication, however, too much iron can cause biological damage. Haipa Xi pyridine (hepcidin was discovered in 2000, a major expression in the liver, iron regulatory functions with a small peptide (1), can induce intestinal epithelial cells or macrophages iron output protein (ferroportin1, Fpn1 endocytosis and degradation to achieve the purpose of reducing serum iron (2). Haipa Xi expression pyridine affected by many factors, such as inflammation and can induce the expression of iron deposition, and anemia, and hypoxia can inhibit the synthesis of (3). a series of studies found that the expression is also affected by pyridine Hai Paxi bone morphogenetic protein (bone morphogenetic protein, BMP’s influence (4), and BMP proteins involved in the process of bone formation, and bone formation, calcium is one of the basic ion. With the age-related increased incidence of osteoporosis, while the phenomenon of iron deposition have occurred in this series of results indicate body iron homeostasis may be related to the close link between calcium met