Resistance gene Topo Ⅱ and Ki-67 expression in esophageal squamous cell carcinoma.docVIP

 PAGE \* MERGEFORMAT 8 Resistance gene Topo Ⅱ and Ki-67 expression in esophageal squamous cell carcinoma Of: Liu Weijun, Yang Yun-ping, Xu Zhiqiang [Abstract] Objective Topo Ⅱ and Ki-67 expression in esophageal squamous cell carcinoma and its relationship with tumor differentiation, lymph node metastasis. Methods immunohistochemistry in 75 cases of esophageal squamous cell carcinoma and Topo Ⅱ expression of Ki-67. Results Topo Ⅱ and ki-67 expression and differentiation of esophageal squamous cell carcinoma and lymph node metastasis are closely related (P lt;0.05, and Topo Ⅱ and ki-67 expression with a strong consistency. Conclusion The detection of Topo Ⅱ and ki-67 expression could be used as an important indicator of prognosis in esophageal squamous cell carcinoma. [Keywords:] esophageal squamous cell carcinoma, Topo Ⅱ, ki-67, immunohistochemistry ABSTRACT Objective To discuss the expression of Topo II and Ki-67 in esophageal sqauamous cell carcinoma and their relationship with the histodifferentiation grades and lymph node metastasis. Methods Immunohistochemistry was applied to study the expression.Results Topo II and Ki-67 were closely related to the histodifferentiation grades and lymph node metastasis of esophageal squamous cell carcinoma, and there existed a great consistence between the positive expression of Topo II and Ki-67.Conclusions The expression of Topo II and Ki-67 can be used as the important index in judging the prognosis of esophageal squamous cell carcinoma. KEYWORDS esophageal squamous cell carcinoma Topo II Ki-67 immunohistochemistry DNA topoisomerase (Topo Ⅱ) is a nuclear enzyme, is the enzyme necessary for DNA replication, but also some anticancer drugs, “target molecules”, the combination of anticancer drugs through the exercise of its anti-tumor effect. When the gene mutation, or the transcription level of the enzyme activity decreased with the combination of anti-cancer drugs can not be resistant, so can not play the