Retinoblastoma gene therapy research progress.doc

 PAGE \* MERGEFORMAT 17 Retinoblastoma gene therapy research progress [Abstract] Gene Therapy retinoblastoma (retinoblastoma, RB in recent years a new type of treatment. We suicide genes, tumor suppressor genes, anti-angiogenic gene in the three aspects of gene therapy RB status, progress and problems as related reviewed. [Keywords:] retinoblastoma, gene therapy Abstract ?r Gene therapy of retinoblastoma (RB) is a new type of treatment in recent years. In this paper, We make a review about gene therapy status, progress and problems of RB from three aspects of suicide genes, tumor suppressor genes, anti angiogenic genes. KEYWORDS: retinoblastoma; gene therapy 0 Introduction Retinoblastoma (retinoblastoma, RB eye disease in infants and young children is the most serious nature, the most damaging is a malignant cancer. RB patients with the treatment of most eye enucleation, local conservative treatment, including chemotherapy, photocoagulation, cryotherapy , heat treatment. Gene therapy is a hot variety of tumor therapy, because tumors are often associated with variation of the human body or the abnormal expression of genes closely related to gene therapy is intended to level from gene to correct these anomalies. As target tissue for gene therapy, the eye due to its special location and structure, easy to accurately target gene into target cells, has a unique advantage. On the RB gene therapy for more than ten years, is now on its research in recent years situation, problems and development direction to be reviewed. A suicide gene therapy Suicide gene therapy, also known as drug-sensitive gene therapy, namely the use of transgenic methods prodrug enzyme gene into tumor cells, and its gene products can the original non-toxic drugs into cytotoxic substances, which kill cells [1] . which the herpes simplex virus thymidine kinase (herpes simplex virus thymi dine kinase, HSV tk) gene into tumor cells expressed, the combination of ganciclovir