RNA interference in the progress of retinal diseases the new.doc

 PAGE \* MERGEFORMAT 21 RNA interference in the progress of retinal diseases the new [Abstract] RNA interference (RNAi found that people changed the traditional understanding of cellular gene regulation. This technology has the unparalleled advantage of traditional treatment methods and potential, so in recent years more and more attention by ophthalmologists around the world. At present, although there are still many clinical problems, but RNAi treatment of eye diseases will surely bring new prospects. we RNAi in the eyes of research are reviewed. [Keywords:] RNA interference, fundus, gene silencing Study on RNA interference technology in fundus diseases Bo Meng, Ning Yu Lei Foundation item: Program of Department of Education in Shandong Province, China (No.J05L12) Department of Ophthalmology, the Affiliated Hospital of Binzhou Medical College, Binzhou 256603, Shandong Province, China Abstract The discovery of RNA interference (RNAi) has changed people’s traditional concepts of the gene.This technique posseses advantages and potentials that traditional therapies can not compare especially in terms of its specificity and efficiency, and it is drawing more and more attentions from ophthalmologists all over the world these year. Although there are still a lot of problems in clinical use at present, various kinds of related experimental results make us firmly believe that RNAi will surely bring a new epoch for curing diseases in ophthalmology.This article provides an overview on some of the latest advances in fundus. ?r KEYWORDS: RNA interference; fundus diseases; gene silencing 0 Introduction RNA interference (RNA Interference, RNAi is mRNA degradation caused by post-transcriptional gene silencing (Post transcriptional Gene Silencing, PTGS [1]. The application of this technology for in vivo and in vitro gene expression in mice provides a new method [ 1]. Although siRNAs and antisense oligonucleotides through Waston Cric