SDF1-CXCR4 biological function and ischemic heart disease in stem cell therapy research progress.doc

 PAGE \* MERGEFORMAT 22 SDF1/CXCR4 biological function and ischemic heart disease in stem cell therapy research progress Of: Chenzhong Pu, Li Yongjun, Gen-Shan Ma [Keywords:] stromal cell derived factor 1; CXC cytokine receptor family of 4; ischemic heart disease; stem cell therapy; Literature Review Stromal cell derived factor -1 (stromal cell derived factor l, SDF 1) is produced by the bone marrow stromal cells CXC chemokines, CXC family cytokine receptor 4 (CXCR4) is known only by the SDF 1 body. At first, SDF 1/CXCR4’s research focuses on blood diseases and AIDS. Since its discovery in 1997 of bone marrow stem cells have obvious chemotaxis, the migration of stem cells on repairing damaged by reports of lesions gradually increased, such as in ischemic brain tissue [1], cardiac tissue [2], limb muscle tissue [3], the chemokine SDF 1 significantly increased, prompting adult stem cells migrated to lesions and accelerate the repair of damaged tissue regeneration. 1 SDF 1/CXCR4 the structure and biological function 1.1 Structure SDF 1 1994, Nagasawa et al [4] in mouse bone marrow stromal cells secrete cytokines pA6 found, because the first B cells play an important role in proliferation and differentiation are known as B cell growth-stimulating factor before. According to its amino acid sequence N-2 amino acid cysteine #8203;#8203;is separated from the other one will be classified as a CXC chemokine subfamily, and was named CXCL12. human SDF 1 gene is located on human chromosome 10q11.1, and bone marrow, brain, heart, kidney, liver, thymus and other organs in the continuous expression. CXCR4 specific receptor for the SDF 1, the gene encoding 352 amino acid coding genes in human chromosome 2q21, is highly conserved with seven transmembrane G protein-coupled domain of the receptor. CXCR4 expression in bone marrow, umbilical cord blood and mobilized peripheral blood derived CD34 + cells, but also in a variety of non-hematopoietic cells and organs e