18F-FDG PETCT在探测卵巢癌术后复发及转移中的价值.pdfVIP

- 376- 核医学 NUCLEAR MEDICINE 18F- FDG PET/CT在探测卵巢癌术后复发 及转移中的价值 陈香赵晋华宋建华汪太松刘长存 [摘要]目的:评价咋-FDG PET/CT显像在探测卵巢癌术后复发、转移病灶中的应用价值。方法:回顾性分析70 例卵巢癌术后患者的全身PET/CT显像结果，与血清CA125及B超、 CT等影像学资料进行比较。确诊依据为手 术病理检查、多种影像学检查和临床随访。结果: 70例卵巢癌术后患者中42例确诊有肿瘤复发、转移， PET/CT 探测卵巢癌术后复发转移的灵敏度、特异性、准确性分别为90.5% 、 89.3% 、 85.7%0 CA125升高的30例患者均 有复发， PET/CT检出其中29例，常规影像学检出25例; CA125正常的40例患者中12例有转移， PET/CT检出其 中9例，常规影像学检出7例。结论: 18F_FDG PET/CT显像对卵巢癌复发、转移的检测具有较高的灵敏度和特异 性，尤其对CA125升高患者PET/CT阳性检出率更高，使分期更准确。 [关键词]卵巢肿瘤z 复发g 转移; PET/CT 申固分类号: R737.31 文献标等码:A 文章编号: 1006 - 5741 (2013) - 04 - 0376 - 05 Value of 18F_FDG PET/CT in Detecting the Recurrence or Metastasis of Postoperative Ovarian Cancer CHEN Xiang, ZHAO Jin-hua, SONG Jian-hua, WANG Tai-song, LIU Chang-cun [Abstract] Purpose: To evaluate the clinical value of 咋-FDG PET/CT in detecting the recurrence or metastasis of postoperative ovarian cancer. Methods: The whole body PET/CT was performed in 70 patients with ovarian cancer. The diagnosis of recurrence or metastasis was based on pathologic examination, multi- modality imaging and clinical follow-up. Results: Of all 70 cases, 42 patients had recurrence or metastasis. The sensitivity, specificity and accuracy of PET/CT in detecting recurrence or metastasis were 90.5% , 89.3% and 85.7%. Thirty patients, who were with increased serum carbohydrate antigen(CA)125, all had recurrence or metastasis, PET/CT detected 29 of them and conventional imaging detected 25. Of 40 patients who were with normal CA125 level, 12 had recurrence or metastasis , PET/CT detected 9 and conventional imaging detected 7. Conciusion: 18F_FDG PET/CT can detect the recurrence or metastasis of ovarian cancer with high sensitivity and specificity especially in patients with increased CA125 level, and it is helpful to enhance the accuracy of clinical staging. [ Key words] Ovarian neoplasm; Recurrence; Metastasis; PET/CT 卵巢癌是妇科常见的恶性肿瘤，死亡率居妇科恶 性肿瘤之首。影响卵巢癌患者预后的主要因素是肿瘤 复发，因此及时发现肿瘤复发、转移，行再次肿瘤细 胞减灭术，捕以放化疗有助于延长患者生命。临床通 常以血清肿瘤标志物CA125