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Association of Glutathione S transferases Polymorphisms with Glaucoma A Meta-Analysis.doc

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Association of Glutathione S transferases Polymorphisms with Glaucoma A Meta-Analysis

AssociationofGlutathioneStransferasesPolymorphisms withGlaucoma:AMeta-Analysis YiboYu1,YuWeng2,JingGuo3,GuangdiChen3*,KeYao1* 1EyeCenterofthe2nd AffiliatedHospital,ZhejiangUniversitySchoolofMedicine,Hangzhou,China, 2DepartmentofClinicalLaboratory,SirRunRunShawHospital, ZhejiangUniversitySchoolofMedicine,Hangzhou,China,3DepartmentofPublicHealth,ZhejiangUniversitySchoolofMedicine,Hangzhou,China Abstract Background: Glutathione S transferase (GST) polymorphisms have been considered risk factors for the development of glaucoma, including primary open angle glaucoma (POAG) and other types of glaucoma. However, the results remain controversial.Inthisstudy,wehaveconductedameta-analysistoassesstheassociationbetweenpolymorphismsofGSTM1, GSTT1andGSTP1andglaucomarisk. Methods: Published literature from PubMed and other databases were retrieved. All studies evaluating the association between GSTM1, GSTT1 and GSTP1 polymorphisms and glaucoma risk were included. Pooled odds ratio (OR) and 95% confidenceinterval(CI)werecalculatedusingrandom-orfixed-effectsmodel. Results:TwelvestudiesonGSTM1(1109casesand844controls),tenstudiesonGSTT1(709casesand664controls)andfour studies on GSTP1 (543 cases and 511 controls) were included. By pooling all the studies, either GSTM1 or GSTT1 null polymorphismwasnotassociatedwithaPOAGrisk,andthisnegativeassociationmaintainedinCaucasian.TheGSTP1Ile 105ValpolymorphismwassignificantlycorrelatedwithincreasedPOAGriskamongCaucasianinarecessivemodel(Val/Val vs. Ile/Ile+Ile/Val: OR, 1.62, 95%CI: 1.00–2.61). Interestingly, increased glaucoma risk was associated with the combined GSTM1andGSTT1nullgenotypes(OR,2.20;95%CI,1.47–3.31),andwiththecombinedGSTM1nullandGSTP1Valgenotypes (OR,1.86;95%CI,1.15–3.01). Conclusions: This meta-analysis suggests that combinations of GST polymorphisms are associated with glaucoma risk. Given the limited sample size, the associations between single GST polymorphism and glaucoma risk await further investigation. Citation:Y