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Atypical Human Infections by Animal Trypanosomes
Review
AtypicalHumanInfectionsbyAnimalTrypanosomes
PhilippeTruc1*,PhilippeBu¨scher2,Ge′rardCuny1,MaryIsabelGonzatti3,JeanJannin4,PrashantJoshi5,
PrayagJuyal6,Zhao-RongLun7,RaffaeleMattioli8,EtiennePays9,PereP.Simarro4,MartaMaria
GeraldesTeixeira10,LouisTouratier11,PhilippeVincendeau12,MarcDesquesnes13
1Institut de Recherche pour le De′veloppement (IRD), UMR InterTryp 177 IRD/CIRAD, Campus International de Baillarguet, Montpellier, France, 2Institute of Tropical
Medicine,Antwerp,Belgium,3UniversidadSimo′nBol?′var,DepartamentodeBiolog?′aCelular,Caracas,Venezuela,4WorldHealthOrganization,InnovativeandIntensified
DiseaseManagement,NeglectedTropicalDiseasesControl,Geneva,Switzerland,5IndiraGandhiGovernmentMedicalCollege,Nagpur,India,6GuruAngadUniversity,
Ludhiana,India,7ZhongshanSchoolofMedicine,SunYat-SenUniversity,Guangzhou,ThePeople’sRepublicofChina,8FoodandAgriculturalOrganizationoftheUnited
Nations,Rome,Italy,9Universite′ LibredeBruxelles,LaboratoryofMolecularParasitology,Gosselies,Belgium, 10UniversityofSa?o Paulo,Sa?o Paulo,Sa?o Paulo,Brazil,
11OIEadhocGrouponNonTsetseTransmittedAnimalTrypanosomoses,Diagnosis,WorldOrganizationforAnimalHealth,Paris,France,12Universite′ deBordeaux2,
UMRInterTryp177IRD/CIRAD,LaboratoryofBiologyandParasitology,Bordeaux,France,13CentredeCoope′ration InternationaleenRechercheAgronomiquepourle
De′veloppement(CIRAD),UMRInterTryp177IRD/CIRAD,KasetsartUniversity,Bangkok,Thailand
[4]. T. lewisi is a worldwide non-pathogenic parasite of rats
transmittedbyfleas[1].
Abstract: The two classical forms of human trypanoso-
moses are sleeping sickness due to Trypanosoma brucei
gambiense or T. brucei rhodesiense, and Chagas disease
due to T. cruzi. However, a number of atypical human
HumanspossessaninnateprotectionagainstmostTrypanosoma
species[5].However,19casesofatypicalhumantrypanosomoses
(a-HT)causedbyT.b.brucei[1,6–8],T.vivax[1],T.congolense[9],
infectionscausedbyotherT.species(orsub-species)have
T.evansi[10–13]andT.le
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