Automated measurement of three-dimensional cerebral cortical thickness in Alzheimer’s patients using localized gradient vector trajectory in fuzzy membership maps.docVIP

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Automated measurement of three-dimensional cerebral cortical thickness in Alzheimer’s patients using localized gradient vector trajectory in fuzzy membership maps.doc

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Automated measurement of three-dimensional cerebral cortical thickness in Alzheimer’s patients using localized gradient vector trajectory in fuzzy membership maps

J. Biomedical Science and Engineering, 2013, 6, 327-336 JBiSE /10.4236/jbise.2013.63A042 Published Online March 2013 (/journal/jbise/) Automated measurement of three-dimensional cerebral cortical thickness in Alzheimer’s patients using localized gradient vector trajectory in fuzzy membership maps Chiaki Tokunaga , Hidetaka Arimura , Takashi Yoshiura , Tomoyuki Ohara , Yasuo Yamashita , 1 2 3 4 1,5 1 5 1 3 2 Kouji Kobayashi , Taiki Magome , Yasuhiko Nakamura , Hiroshi Honda , Hideki Hirata , 2 2 Masafumi Ohki , Fukai Toyofuku 1 Division of Radiology, Department of Medical Technology, Kyushu University Hospital, Fukuoka, Japan 2 Department of Health Sciences, Faculty of Medical Sciences, Kyushu University, Fukuoka, Japan 3 Department of Clinical Radiology, Graduate School of Medical Sciences, Kyushu University, Fukuoka, Japan 4 Department of Neuropsychiatry, Graduate School of Medical Sciences, Kyushu University, Fukuoka, Japan 5 Department of Health Sciences, Graduate School of Medical Sciences, Kyushu University, Fukuoka, Japan Email: arimurah@med.kyushu-u.ac.jp Received 14 January 2013; revised 22 February 2013; accepted 28 February 2013 ABSTRACT Keywords: Alzheimer’s Disease (AD); Fuzzy C-Means Clustering (FCM); Three-Dimensional Cerebral Cortical Thickness; Localized Gradient Vector Our purpose in this study was to develop an auto- mated method for measuring three-dimensional (3D) cerebral cortical thicknesses in patients with Alz- heimer’s disease (AD) using magnetic resonance (MR) images. Our proposed method