Chemicals, Climate, and Control Increasing the Effectiveness of Malaria Vector Control Tools by Considering Relevant Temperatures.docVIP
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Chemicals, Climate, and Control Increasing the Effectiveness of Malaria Vector Control Tools by Considering Relevant Temperatures
Opinion
Chemicals,Climate,andControl:Increasingthe
EffectivenessofMalariaVectorControlToolsby
ConsideringRelevantTemperatures
KateyD.Glunt1,JustineI.Blanford2,KrijnP.Paaijmans3*
1Center for Infectious Disease Dynamics and Department of Biology, The Pennsylvania State University, University Park, Pennsylvania, United States of America,
2GeoVISTA Center, Department of Geography, The Pennsylvania State University, University Park, Pennsylvania, United States of America, 3Barcelona Centre for
InternationalHealthResearch(CRESIB,HospitalCl?′nic-UniversitatdeBarcelona),Barcelona,Spain
Introduction
most malaria transmission settings, the
observed mean temperatures range from
approximately 18 (cooler highland areas)
to26uC.
involved in degradation of insecticides,
and nervous system sensitivity [8] are
highly temperature-dependent. As mos-
quito body temperature changes with its
surroundings, environmental temperature
has the potential to influence the toxicity
ofinsecticides.Thiseffectisquantifiedby
Malaria vector control currently relies
almostexclusivelyonkillingadultmosqui-
toes with chemical insecticides. Insecti-
cide-treated nets (ITNs), long-lasting in-
secticide-treated nets(LLINs), and indoor
residualsprays(IRS)aimtorepel,disable,
and/or kill mosquitoes on contact. While
these tools have proven to be extremely
successful in reducing disease incidence
and mortality [1], insecticide resistance is
ontheriseandaresurgenceofmalariais
feared [2]. To mitigate the effects of
resistance, the development of new insec-
ticides andformulations for useinLLINs
and for IRS remains a research priority
[3]. In this paper we argue that, to
increase the effectiveness of the chemical
arsenalavailable,weneedtoconsiderthe
relevantmicroclimaticconditionsinwhich
these tools are deployed. We will discuss
howtemperatureinparticularcaninteract
with the conventional use of chemicals
withinhouses,andbroadenourdiscussion
to consider its potential influence on the
use of semiochemicals to l
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