原创力文档The WW-HECT protein Smurf2 interacts with the Docking Protein NEDD9HEF1 for Aurora A activation 英文论文文献.docVIP
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The WW-HECT protein Smurf2 interacts with the Docking Protein NEDD9HEF1 for Aurora A activation 英文论文文献
Mooreetal.CellDivision2010,5:22
/content/5/1/22
RESEARCH
OpenAccess
TheWW-HECTproteinSmurf2interactswiththe
DockingProteinNEDD9/HEF1forAuroraA
activation
FinolaEMoore1?,EvanCOsmundson1?,JenniferKoblinski2,3,ElenaPugacheva4,EricaAGolemis5,DipankarRay1,6*,
HiroakiKiyokawa1,3*
Abstract
Themulti-functionaladaptorproteinNEDD9/HEF1/Cas-Lregulatescellmotility,invasionandcellcycleprogression,
andplayskeyrolesincancerprogressionandmetastasis.NEDD9islocalizedtothecentrosomeandisrequiredfor
activationofAuroraAkinaseinmitosis.HerewedemonstratethattheHECT-WWproteinSmurf2physicallyassoci-
ateswithNEDD9and
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