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TIGRESS Trustful Inference of Gene REgulation using Stability Selection 英文论文文献
Hauryetal.BMCSystemsBiology2012,6:145
/1752-0509/6/145
METHODOLOGY ARTICLE
OpenAccess
TIGRESS:TrustfulInferenceofGeneREgulation
usingStabilitySelection
Anne-ClaireHaury1,2,3,FantineMordelet4,PaolaVera-Licona1,2,3andJean-PhilippeVert1,2,3*
Abstract
Background: Inferringthestructureofgeneregulatorynetworks(GRN)fromacollectionofgeneexpressiondatahas
manypotentialapplications,fromtheelucidationofcomplexbiologicalprocessestotheidenti?cationofpotential
drugtargets.Itishoweveranotoriouslydi?cultproblem,forwhichthemanyexistingmethodsreachlimitedaccuracy.
Results: Inthispaper,weformulateGRNinference
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