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Towards a quantitative understanding of the MITF-PIAS3-STAT3 connection 英文论文文献
Thingnesetal.BMCSystemsBiology2012,6:11
/1752-0509/6/11
RESEARCH ARTICLE
OpenAccess
Towardsaquantitativeunderstandingofthe
MITF-PIAS3-STAT3connection
JosefThingnes1*,TimothyJLavelle3,ArneBGjuvsland1,StigWOmholt2andEivindHovig3,4,5
Abstract
Background:Expressionofthetwotranscriptionfactorsmicrophthalmia-associatedtranscriptionfactor(MITF)and
signaltransducerandactivatoroftranscription3(STAT3)aretightlyconnectedtocellproliferationandsurvival,
andareimportantformelanocytedevelopment.Theco-regulationofMITFandSTAT3viatheirbindingtoa
commoninhibitorProteinInhibitorofActivatedSTAT3(PIAS3)isintrigu
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