Towards Cancer Hybrid Automata 英文论文文献.docVIP

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Towards Cancer Hybrid Automata 英文论文文献.doc

Towards Cancer Hybrid Automata 英文论文文献

TowardsCancerHybridAutomata LoesOldeLoohuis AndreasWitzel BudMishra CUNYTheGraduateCenter DepartmentofComputerScience NYU CourantInstitute l.oldeloohuis@ awitzel@ mishra@ ThispaperintroducesCancerHybridAutomata(CHAs),aformalismtomodeltheprogressionof cancersthroughdiscretephenotypes. Theclassi?cationofcancerprogressionusingdiscretestates likestagesandhallmarkshasbecomecommoninthebiologyliterature,butprimarilyasanorganizing principle,andnotasanexecutableformalism.Theprecisecomputationalmodeldevelopedhereaims toexploitthisuntappedpotential,namely,throughautomaticveri?cationofprogressionmodels

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