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Towards Cancer Hybrid Automata 英文论文文献
TowardsCancerHybridAutomata
LoesOldeLoohuis
AndreasWitzel
BudMishra
CUNYTheGraduateCenter
DepartmentofComputerScience
NYU
CourantInstitute
l.oldeloohuis@
awitzel@
mishra@
ThispaperintroducesCancerHybridAutomata(CHAs),aformalismtomodeltheprogressionof
cancersthroughdiscretephenotypes. Theclassi?cationofcancerprogressionusingdiscretestates
likestagesandhallmarkshasbecomecommoninthebiologyliterature,butprimarilyasanorganizing
principle,andnotasanexecutableformalism.Theprecisecomputationalmodeldevelopedhereaims
toexploitthisuntappedpotential,namely,throughautomaticveri?cationofprogressionmodels
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