Translational research in sepsis - an ultimate challenge 英文论文文献.docVIP

Kampmeieretal.ExperimentalTranslationalStrokeMedicine2011,3:14 /content/3/1/14 REVIEW OpenAccess Translationalresearchinsepsis-anultimate challenge? TimGKampmeier,ChristianErtmerandSebastianRehberg* Abstract Intheeraofevidence-basedmedicine,large,randomized,controlled,multicenterstudiesrepresentthe“summitof evidence”.Incontrasttospecialtieslikecardiology,themajorityofrandomized,controlledtrialsincriticalcare medicine,however,havefailedtodemonstrateasurvivalbenefit;notably,despiteencouragingresultsfrom experimentalandphase-IIclinicalstudies.Thedifficultyintranslatingourtheoreticalknowledgeint