Transdifferentiation from cornea to lens in Xenopus laevis depends on BMP signalling and involves upregulation of Wnt signalling 英文论文文献.docVIP
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Transdifferentiation from cornea to lens in Xenopus laevis depends on BMP signalling and involves upregulation of Wnt signalling 英文论文文献
DayandBeckBMCDevelopmentalBiology2011,11:54
/1471-213X/11/54
RESEARCH ARTICLE
OpenAccess
Transdifferentiationfromcorneatolensin
XenopuslaevisdependsonBMPsignallingand
involvesupregulationofWntsignalling
RobertCDay1,2 andCarolineWBeck1,3*
Abstract
Background:SurgicalremovalofthelensfromlarvalXenopuslaevisresultsinarapidtransdifferentionofcentral
cornealcellstoformanewlens.Thetriggerforthisprocessisunderstoodtobeaninductioneventarisingfrom
theunprecedentedexposureofthecorneatothevitreoushumourthatoccursfollowinglensremoval.The
molecularidentityofthistriggerisunknown.
Results:Here,wehaveusedafu
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