Transcriptome analysis reveals a major impact of JAK protein tyrosine kinase 2 (Tyk2) on the expression of interferon-responsive and metabolic genes 英文论文文献.docVIP

Vogl et al. BMC Genomics 2010, 11:199 /1471-2164/11/199 RESEARCH ARTICLE Open Access Transcriptome analysis reveals a major impact of Research article JAK protein tyrosine kinase 2 (Tyk2) on the expression of interferon-responsive and metabolic genes Claus Vogl*1, Thomas Flatt2, Bernd Fuhrmann1, Elisabeth Hofmann1, Barbara Wallner1, Rita Stiefvater1, Pavel Kovarik3, Birgit Strobl1 and Mathias Müller*1,4 Abstract Background: Tyrosine kinase 2 (Tyk2), a central component of Janus kinase/signal transducer and activator of transcription (JAK/STAT) signaling, has major effects on innate i