Transcriptome and proteome analysis of tyrosine kinase inhibitor treated canine mast cell tumour cells identifies potentially kit signaling-dependent genes 英文论文文献.docVIP
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Transcriptome and proteome analysis of tyrosine kinase inhibitor treated canine mast cell tumour cells identifies potentially kit signaling-dependent genes 英文论文文献
Klopfleischetal.BMCVeterinaryResearch2012,8:96
/1746-6148/8/96
RESEARCH ARTICLE
OpenAccess
Transcriptomeandproteomeanalysisof
tyrosinekinaseinhibitortreatedcanine
mastcelltumourcellsidentifiespotentially
kitsignaling-dependentgenes
RobertKlopfleisch1*,AnjaMeyer1,PatriciaSchlieben1,AngelikaBondzio2,ChrisWeise3,DidoLenze4,
MichaelHummel4,RalfEinspanier2andAchimDGruber1
Abstract
Background:CaninemastcelltumourproliferationdependstoalargeextentontheactivityofKIT,atyrosine
kinasereceptor.InhibitorsoftheKITtyrosinekinasehaverecentlybeenintroducedandsuccessfullyappliedasa
therapeuticagentforthistu
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