Transcriptional double-autorepression feedforward circuits act for multicellularity and nervous system development 英文论文文献.docVIP

Regulator chain Feedforward circuit backbone (FFC) a X Y X Y X Y Target (Z) Regulator mode-coherence Z = TF Z = Ef X X X Y Y Y ????? *** ????? ????? *** Coherent type 1 Incoherent type 1 Coherent type 2 Incoherent type 2 ????? ?????? ?????? ?????? ?????? ?????? ?????? ?????? ????? X Y Z-score b ?? ?? ?? ? ? ? X Y X Y X Y Target (Z) Autoregulation configuration Z = TF Z = Ef ? Double autoregulation X Y Y ????? ** ????? **** ?????? ?????? ????? ????? Intermediary-only X ????? ????? autoregulated ***P 0.005 ** P 0.03 Originating-only ??????**** ?????? * X X Y Y autoregulated * ??????