TurboFold Iterative probabilistic estimation of secondary structures for multiple RNA sequences 英文论文文献.docVIP

Harmancietal.BMCBioinformatics2011,12:108 /1471-2105/12/108 RESEARCH ARTICLE OpenAccess TurboFold:Iterativeprobabilisticestimationof secondarystructuresformultipleRNAsequences ArifOHarmanci1,4,GauravSharma 1,3,4* andDavidHMathews2,3,4 Abstract Background:Thepredictionofsecondarystructure,i.e.thesetofcanonicalbasepairsbetweennucleotides,isa firststepindevelopinganunderstandingofthefunctionofanRNAsequence.Themostaccuratecomputational methodspredictconservedstructuresforasetofhomologousRNAsequences.Thesemethodsusuallysufferfrom highcomputationalcomplexity.Inthispaper,TurboFold,anovelandeffici