原创力文档Wntbeta-catenin signaling activates microRNA-181 expression in hepatocellular carcinoma 英文论文文献.docVIP
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Wntbeta-catenin signaling activates microRNA-181 expression in hepatocellular carcinoma 英文论文文献
Jietal.CellBioscience2011,1:4
/content/1/1/4
Cell Bioscience
RESEARCH
OpenAccess
Wnt/beta-cateninsignalingactivatesmicroRNA-
181expressioninhepatocellularcarcinoma
JunfangJi1,TaroYamashita1,2,XinWWang1*
Abstract
Background:Hepatocellularcarcinoma(HCC)isamalignantcancerwithanobservableheterogeneityand
microRNAsarefunctionallyassociatedwiththetumorigenesisofHCC.WerecentlyidentifiedthatEpCAM(CD326)-
positivecellsisolatedfromalpha-fetoprotein(AFP)-positiveHCCsamplesarehepaticcancerstemcells(HepCSCs).
EpCAM+AFP+HepCSCshaveanactivatedWnt/b-cateninsignalingwithaparallelincreasedexpressionofallfour
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