Fatal Leptospirosis Case in Pediatric Patient Clinical Case.docVIP

Open Journal of Medical Microbiology, 2013, 3, 12-17 /10.4236/ojmm.2013.31003 Published Online March 2013 (/journal/ojmm) Fatal Leptospirosis Case in Pediatric Patient: Clinical Case Laura I. Santiago García , Citlalli Martínez Cruz , Irma Zamudio Lugo , 1 1 2 3 1* Beatriz Rivas Sánchez 3 , Oscar Velasco Castrejón , Joel Navarrete Espinosa 1 Coordination of Epidemiologic Surveillance, Unit of Public Health, IMSS, Mexico City, Mexico Division of Hospital Epidemiologic, Children’s Hospital, CMN Century XXI, IMSS, Mexico City, Mexico Clinic of Tropical Medicine, Unit of Experimental Medicine, School of Medicine, UNAM, Mexico 2 3 Email: joel.navarrete@imss.gob.mx * Received December 6, 2012; revised January 11, 2013; accepted January 31, 2013 ABSTRACT Introduction: Leptospirosis is a worldwide zoonosis. It is transmitted through the urine of infected animals. Currently, there is an increase of reports in many countries. In humans, it presents an ample clinical spectrum, which goes from an asymptomatic infection up to Weil syndrome, which is generally fatal. Clinical Case: A male, 6 years of age, who started with onset fever and jaundice, handled in private means, diagnosed as viral hepatitis “A” and was referred to an institutional hospital where hepatomegaly and splenomegaly were detected. His evolution was towards graveness and, therefore, he was referred to a third level hospital with reactive Hepatitis diagnosis and to rule out lymphoma. On ad- mission, he presented liver and kidney failure, as well as metabolic acidosis and pulmonary haemorrhage that led to death 6 hours later. Confirmatory tests for hepatitis were negative; biopsies were taken post-mortem for Leptospira di- agnosis, which were positive in liver and kidney. Conclusions: Le