晚期肺发育障碍与支气管肺发育不良研究进展.pdf

亘匿』L型堂苤查!Q!!生!!旦筮竺鲞筮!魍!堕!里盟i坐：盟!!!Q!i：y!!：丝：堕!：! ·综述· 晚期肺发育障碍与支气管肺发育不良研究进展 陈筱青蒋炜(综述)吴升华(审校) 【摘要】 晚期肺发育发生在胚胎小管期以后，这一阶段初级隔膜转化为次级隔膜，产生大量的小型肺 泡，扩大气体交换的表面积，次级化分隔作用和肺血管结构的改变是晚期肺发育的关键环节。近年来研究 表明晚期肺发育障碍参与了支气管肺发育不良的病理过程。支气管肺发育不良是一种肺泡发育障碍的新 生儿肺部疾病，由炎症、气压伤和氧中毒等多种因素所致，和晚期肺发育障碍互为因果。该文对晚期肺发 育障碍与支气管肺发育不良的最新研究进展作一综述。 【关键词】支气管肺发育不良；肺泡化；肺发育；早产儿 Advancesinarrestedlate and Chen developmentbronchopulmonarydysplasiaXiaoqing，JiangWei， lung First Medical Wu Pediatrics．the Shenghua．Departmentof AffiliatedHospitalofNanjing University．Nanjing 210029，China oflate isdisturbedinbronchopulmonarydysplasia(BPD)． 【Abstract】Theprocess lungdevelopment Oneofthe inlate is which arisefrom keys lungdevelopmentsecondaryseptation，insecondarysepta primary ofsmall increasethesurfaceareaof alveoli，which septa，producingplenty significantly gasexchange．Secondary with tothe structureofthe whichminimizethedistance architectural vascular septation，together changes lung betweenthebloodandthe the oflate isadiseaseof in— inspiredair，aletargets lungdevelopment．BPDpremature is fantsinwhich ofthealveolistuntedcaused factors development bymany includingvolutrauma，inflammation， and with later oftheimmatureremains oxygentoxicity．Comparedearlylungdevelopment，thedevelopment lung is of late andBPD． unclear．Thisto remarkablelatestresearcharrested lung paper emphasize development