次氯酸荧光探针的研究进展.pdf

DOI: 10.6023/cjoc201511038 综述与进展 有机化学 Chinese Journal of Organic Chemistry REVIEW 次氯酸荧光探针的研究进展 王延宝a,b 赵宝祥*,b (a 济宁学院化学与化工系 曲阜 273155) (b 山东大学化学与化工学院 济南 250100) 摘要 次氯酸(HClO)是生物体内重要的活性氧(ROS)之一, 在人类免疫功能系统中扮演着重要的角色, 有助于对入侵 细菌和病原体进行破坏. 然而, 过量的次氯酸或次氯酸盐会导致组织损伤和一系列疾病, 如动脉硬化、关节炎和癌症 等. 因此, 快速、灵敏、选择性检测生物样品中的 HClO 相当重要. 近年来, 由于具备操作简单、检测限低、低毒性、 高灵敏度和高选择性等多种优势, 荧光探针方法检测次氯酸的研究得到了快速发展. 按照不同的荧光基团综述了近几 年 HClO 荧光探针的设计、合成与应用进展. 关键词 次氯酸; 荧光探针; 活性氧; 生物成像 Recent Progress in Fluorescent Probes for the Detection of Hypochlorous Acid Wang, Yanbaoa,b Zhao, Baoxiang*,b a ( Department of Chemistry and Chemical Engineering, Jining University, Qufu 273155) b ( School of Chemistry and Chemical Engineering, School of Chemistry and Chemical Engineering, Shandong University, Jinan 250100) Abstract Hypochlorous acid (HClO) is one of the biologically important reactive oxygen species (ROS), which plays im- portant roles in the human immune defence system, and contributes to the destruction of invading bacteria and pathogens. But excessive formation of HClO can lead to tissue damage and a series of human diseases, such as atherosclerosis, arthritis and even cancers, etc. Therefore, a rapid, sensitive, and selective detection of HClO in biological samples is important. In recent years, fluorescent