爱信誉图书馆_支气管成形术对呼吸道粘液纤毛清除功能的影响.pdf

2002 5 19 3 　Chin J E p Surg, May 2002, Vol 19, No.3 ·223 · ·· 梁朝阳　孙玉鹗　周乃康　陈东红　刘阳　朱佰锁　王殿军　张光辉 　　【】　　(MCC)。 　 16 , , 。3、7、10 , 。　 [, (P 0.0 1)], 3、7、10 60%、67%76%。 , 。　 , 。 【】　;　;　 Ef fects of bronchoplasty on mucociliary clearance of respiratory tract 　　L IAN G Chaoyang, S UN Y ue, ZHOU Naikang, et al.Detartment of Thoracic S urgery , General Ho p ital of PLA , Beij ing 100853, China 【Abstract】　Objective 　T o investigate the effects of bronchoplasty on mucociliary clearance (MCC)in the early period after operation.Methods 　Si teen adult mongrel dogs were divided into two groups.Dogs in the group A underwent lef t upper sleeve lobectomy and bronchoplasty,while those in the group B received standard left upper lobectomy .The mucociliary clearance was determined by observing the movement of carbon particles through a bronchoscope before and 3, 7, 10 days after operation.The bronchial mucosa blood flow w as measured by laser Doppler velocimetry (LDV )before and 3, 7, 10 days after operation.All dogs were sacrificed on the 10th postoperative day and bronchial samples including the anastomoses were taken out for microscopic (light and electron)analysis.R esults 　MCC of the operated respiratory tract in group A was decreased markedly in the early period after operation (P0.0 1).The bronchial mucosa blood flow distal to anastomosis on 3, 7 and 10 day after operation was decreased to nearly 60%, 67% and 76% of the preoperative level.Light and scanning electron microscopic studies show ed marked focal denudation of ciliary epithelium and scatteredly arranged cilia distal to anastomosis. Conclusion　Bronchoplastic procedures cause significant depression of MCC in the operated respiratory tracts in the early postoperative period.MCC impairment was mainly attributed to structural and func- tional disorders of the components of mucociliary apparat