张新祥《生化分析》0422膜片钳-2.pdfVIP

Applications of Patch Clamp 胡世超1301110260 Kheradpezhouh Et al. Proc. Nati. Acad. Sci. 2014, 111(8): 3176-81. Background • Acetaminophen is the most frequently used analgesic and antipyretic drug available over the counter. • In Western countries, acetaminophen-induced hepatotoxicity is a leading cause of acute liver failure requiring liver transplantation. • The exact pathways of acetaminophen hepatoto- xicity that lead to hepatocellular death are still not completely understood Kheradpezhouh Et al. Proc. N