亚甲基四氢叶酸还原酶基因型对叶酸降同型半胱氨酸的影响.pdfVIP

2011 2 19 2 Chin J Hypertens, February 2011, Vol. 19 No. 2 143 论 著 1 2 2 2 2 3 1 王杨 , 蒋善群 , 秦献辉 , 王旭 , 徐希平 , 肖凡凯 , 赵洛沙 1 , 450052; 2 ; 3 : (H cy) (M TH FR) C677T , H cy , , MTH FR Hcy M TH FR C677T Hcy 233 2 , ( 10 mg) (/ , 10 mg/ 04~ 0 8 mg) , 1/ d, 8 , H cy , MT HFR 677CCCT TT , H cy , 8 TT Hcy 15% , CC/ CT 2% ( P= 0 017) ; / , 8 TT H cy 21% , CC/ CT 9% ( P= 0002) / T T CC/ CT H cy 10 mol/ OR 2 7(P = 0 005) , 8 OR 22( P= 0 043) H cy logistic , , / TT CC/ CT H cy 2 8( P 0 01) ; TT H cy 24 Hcy , M TH FR TT : ; ; ; ; Influence of methylenetetrahydrofolate reductase gene polymorphism on combination of enalapril with folic acid in lowering plasma homocysteine * WANG Yang , JIANG Shanqun, QIN Xianhui, WANG Xu, XU Xi ping, XIAO Fankan, ZHAO uosha * Dep artment of Cardiolog y of First Af f iliated H osp ital of Zhengz hou University , H enan 50052 , China Abstract: Background H igh plasma homocysteine ( H cy) levels and met hylenetetrahydrofolate reduct ase (M TH FR) gene C677T polymorphism are major risk factors for cardiovascular disease. It has become a hot issue in cardiovascular research field t hat folic acid can have an effect on cardiovascular event reduction by low ering H cy levels. Nevertheless, there has been little research conducted at home and abroad on t he relationships among folic acid, MTH FR gene polymorphism and Hcy. Furthermore, there also exist discrepancies in conclusions. O