急性冠脉综合征痰瘀证与炎症关系的临床研究.docVIP

　　急性冠脉综合征痰瘀证与炎症关系的临床研究 【摘要】 目的：本研究试图针对 ACS 痰瘀证研究的空白，从免疫炎症的角度出发，探讨急性冠脉综合征痰瘀证的实质，并分析了炎症因子与血脂分组间的相关性。方法：将 90 例急性冠脉综合征患者按照中医辨证标准分为痰瘀证组（ 55 例） 及非痰瘀证组（ 35 例），另设健康对照组 70 例。分别检测 CRP、FIB、IL-6、TNF-α 及 D － 二聚体在痰瘀证及非痰瘀证组中的数值，分析急性冠脉综合征痰瘀证与炎症相关因子的关系。检测痰瘀证组、非痰瘀证组间 TC、TG 及 LDL-C 的数值变化。结果： 急性冠脉综合征痰瘀证组 CRP、TNF -α 及 D －二聚体显著高于非痰瘀证组（P lt; 0.05、P lt; 0.05、P lt; 0.01），痰瘀证组 FIB、IL－6 虽高于非痰瘀证组，但差异未见显著性（P gt; 0.05）。ACS 痰瘀证组 TC 数值显著高于非痰瘀证组（P ＝ 0.025），其余 TG 及 LDL-C 在两组间的比较未见显著差异（P 均 gt; 0.05）。结论：本研究显示 CRP、TNF -α及 D －二聚体等炎症因子介导的免疫炎症活动与 ACS 痰瘀证的形成密切相关，可能是 ACS 痰瘀证形成的始动因素；而高血 脂是急性冠脉综合征痰瘀证形成的物质基础；CRP、TNF －α、D － 二聚体等免疫、炎症因子有可能成为 ACS 痰瘀证划分的客观指标。 【关键词】 急性冠脉综合征；痰瘀证；炎症介质 〔Abstract〕 Objective Pointing to the vacancy in the research of phlegm-blood stasis syndrome of ACS, ong phlegm-blood stasis syndrome, e kind of inflammation mediums and blood lipid. Methods 90 ACS patients -blood stasis group (55) and non-phlegm -blood stasis group (35) in accordance e differentiation of TCM. 70 healthy people or necrosis factor-alpha ( TNF -α) D-Dimer (D-D) of the phlemgm-blood Stasis group and the non-phlegm- blood stasis group, in the meantime, analyzed the relationship bet-blood stasis of ACS and he inflammation mediums. The variety of the three kinds of lipid (TC, TG, LDL-C) bet-blood stasis group and the non-phlegm-blood stasis group -blood stasis group of ACS -blood stasis group (Plt; 0.05、P lt; 0.05、P lt; 0.01 ). FIB and IL-6 in the phlegm-blood stasis group -blood stasis group, but all the differences erical value of TC -blood stasis group of ACS than that in non-phlegm-blood stasis group (P=0.025 ), but the difference of TG betmunity and inflammation activities leaded by CRP, TNF -α, D-D, et al are highly related to the formation of phlegm-blood stasis syndrome of ACS, and the activities maybe the stimulate factor that accelerate the formation; High blood lipid is the basic substance in the formation of phlegm-blood stasis syndrome of ACS; The immunity and inflammation mediums, such as CRP, TNF -α, D-