Computational Modeling of Microabscess Formation英文文献资料.docVIP

HindawiPublishingCorporation ComputationalandMathematicalMethodsinMedicine Volume2012,ArticleID736394,16pages doi:10.1155/2012/736394 ResearchArticle ComputationalModelingofMicroabscessFormation AlexandreBittencourtPigozzo, GilsonCostaMacedo, RodrigoWeberdosSantos, 1 2 1 andMarceloLobosco 1 1 GraduatePrograminComputationalModeling,UFJF,RuaJos′eLourenc?oKelmers/n,CampusUniversit′ario,BairroS?aoPedro, 36036-900JuizdeFora,MG,Brazil 2 GraduatePrograminBiologicalSciences,UFJF,RuaJos′eLourenc?oKelmers/n,CampusUniversit′ario,BairroS?aoPedro, 36036-900JuizdeFora,MG,Brazil CorrespondenceshouldbeaddressedtoAlexandreBittencourtPigozzo,alexbprr@ Received29June2012;Revised28August2012;Accepted5September2012 AcademicEditor:VladimirBrusic Copyright?2012AlexandreBittencourtPigozzoetal.Thisisan open access article distributedunder theCreativeCommons AttributionLicense,whichpermitsunrestricteduse,distribution,andreproductioninanymedium,providedtheoriginalworkis properlycited. Bacterial infectionscan beoftwo types: acute orchronic. Thechronicbacterial infections arecharacterized bybeingalarge bacterial infection and/or an infection where the bacteria grows rapidly. In these cases, the immune response is not capable ofcompletelyeliminatingtheinfectionwhichmayleadtotheformationofapatternknownasmicroabscess(orabscess).The microabscessischaracterizedbyanareacomprising?uids,bacteria,immunecells(mainlyneutrophils),andmanytypesofdead cells.Thisdistinctpatternofformationcanonlybenumericallyreproducedandstudiedbymodelsthatcapturethespatiotemporal dynamicsofthehumanimmunesystem(HIS).Inthiscontext,ourworkaimstodevelopandimplementaninitialcomputational modeltostudytheprocessofmicroabscessformationduringabacterialinfection. 1.Introduction interact during an immune response. In addition, the model’sparametersre?ectthephysiologicalfeaturesofthe system,makingthemodelappropriateforgeneraluse. The remainder of this paper is organized as follows.