Construction and Control of Genetic Regulatory NetworksA Multivariate Markov Chain Approach英文文献资料.docVIP

Scientific Research Publishing J. Biomedical Science and Engineering, 2008, 1, 15-21 Construction and control of genetic regulatory networks:a multivariate Markov chain approach Shu-Qin Zhang 1, Wai-Ki Ching 2, Yue Jiao 2, Ling-Yun Wu3Raymond H. Chan 4 1 School of Mathematical Sciences, Fudan University, Shanghai, 200433, China. Department of Mathematics, The University of Hong Kong, Pokfulam Road, Hong Kong. Mathematics and SystemSciences, ChineseAcademy of Sciences. 2 Advanced Modeling and Applied Computing Laboratory, 3 Institute of Applied Mathematics, Academy of 4 Department of Mathematics, the Chinese University of Hong Kong, Shatin, N.T., Hong Kong. * Correspondence should be addressed to Shu-Qin Zhang (zhangs@). ABSTRACT [1,2,4,11,15,16,17,21] have been proposed. Among all the models, BNs and PBNs have received much attention. The approach is to model the genetic regu- latory system by a Boolean network and infer the net- work structure from real gene expression data. Then by using the inferred network model, the underlying gene regulatory mechanisms can be uncovered. This is particularly useful as it helps to make useful pre- dictions by computer simulations. We refer readers to the survey paper by Shmulevich et al. [18, 19] and the book by Shmulevich and Dougherty [20]. In the post-genomic era, the construction and control of genetic regulatory networks using gene expression data is a hot research topic. Boolean networks (BNs) and its extension Probabilistic Boolean Networks (PBNs) have been served as an effective tool for this pur- pose. However, PBNs are difficult to be used in practice when the number of genes is large because of the huge computational cost.In this paper,we proposea simplifiedmu