Consumption of Cross-Linked Resistant Starch (RS4XL) on Glucose and Insulin Responses in Humans英文文献资料.docVIP

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Consumption of Cross-Linked Resistant Starch (RS4XL) on Glucose and Insulin Responses in Humans英文文献资料.doc

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Consumption of Cross-Linked Resistant Starch (RS4XL) on Glucose and Insulin Responses in Humans英文文献资料

HindawiPublishingCorporation JournalofNutritionandMetabolism Volume2010,ArticleID651063,6pages doi:10.1155/2010/651063 ClinicalStudy ConsumptionofCross-LinkedResistantStarch(RS4XL )on GlucoseandInsulinResponsesinHumans EnasK.Al-Tamimi, PaulA.Seib, BrianS.Snyder, andMarkD.Haub 1 2 1 1 1 2 DepartmentofHumanNutrition,KansasStateUniversity,Manhattan,KS66506,USA DepartmentofGrainScienceandIndustry,KansasStateUniversity,Manhattan,KS66506,USA CorrespondenceshouldbeaddressedtoMarkD.Haub,haub@ Received19May2009;Revised26June2009;Accepted9July2009 AcademicEditor:MichaelPagliassotti Copyright?2010EnasK.Al-Tamimietal.ThisisanopenaccessarticledistributedundertheCreativeCommonsAttribution License,whichpermitsunrestricteduse,distribution,andreproductioninanymedium,providedtheoriginalworkisproperly cited. Objective.Theobjectivewastocomparethepostprandialglycemicandinsulinemicresponsestonutritionbarscontainingeither cross-linkedRStype4(RS4XL)orstandardwheatstarchinnormoglycemicadults(n=13;age=27±5years;BMI=25±3kg/m ). 2 Methods.Volunteerscompletedthreetrialsduringwhichtheyconsumedaglucosebeverage(GLU),apu?edwheatcontrolbar (PWB),andabarcontainingcross-linkedRS4(RS4XL)matchedforavailablecarbohydratecontent.Serialbloodsampleswere collectedovertwohoursandglucoseandinsulinconcentrationsweredeterminedandtheincrementalareaunderthecurve(iAUC) wascalculated.Results.TheRS4XL peakglucoseandinsulinconcentrationswerelowerthantheGLUandPWB(P .05).The iAUCforglucoseandinsulinwerelowerfollowingingestionofRS4comparedwiththeGLUandPWBtrials.Conclusions .These dataillustrate,forthe?rsttime,thatdirectlysubstitutingstandardstarchwithRS4XL,whilematchedforavailablecarbohydrates, attenuatedpostprandialglucoseandinsulinlevelsinhumans.Itremainstobedeterminedwhetherthisresponsewasduetothe dietary?berand/orresistantstarchaspectsoftheRS4XL bar. 1.Introduction diabetic individuals, positive e?ects on large bowel health and prevention of colonic