Continuous versus bolus nasogastric tube feeding in premature neonates Randomized controlled trial英文文献资料.docVIP

Open Journal of Pediatrics, 2012, 2, 214-218 OJPed /10.4236/ojped.2012.23034 Published Online September 2012 (http://www.SciRP.org/journal/ojped/) Continuous versus bolus nasogastric tube feeding in premature neonates: Randomized controlled trial* M. van der Star , Ben Semmekrot , Esmeralda Spanjaards , Anne Schaafsma 1,2 1# 1 3 1 2 3 Department of Pediatrics, Canisius-Wilhelmina Hospital, Nijmegen, The Netherlands University Medical Center St. Radboud, Nijmegen, The Netherlands FrieslandCampina, Innovation Infant Toddler Nutrition, Leeuwarden, The Netherlands Email: b.semmekrot@cwz.nl # Received 13 March 2012; revised 11 April 2012; accepted 28 May 2012 ABSTRACT 1. INTRODUCTION Background: Whether premature infants should be fed by bolus or continuous gavage feeding, is still a matter of debate. A recent Cochrane analysis re- vealed no difference. Study design and methods: We carried out a randomized controlled trial in prema- ture infants on continuous versus bolus nasogastric tube feeding, to search for differences with respect to number of incidents, growth, and time to reach full oral feeding. In total, 110 premature neonates (gesta- tional age 27 - 34 weeks) were randomly assigned to receive either continuous or bolus nasogastric tube feeding. Basic characteristics were comparable in both groups. Results: No significant difference in weight gain could be detected between the two groups, mean weight gain amounting 151.6 (108.9 - 194.3) and 152.4 (102.2 - 202.6) grams per week in the continu- ous and bolus group, respectively. No significant dif- ferences were found between both groups in the time needed to achieve full oral feeding (8 oral feedings per day), full oral feeding being achieved at day 31 (range 19 - 43) and d