Contrast Enhancement of Optical Coherence Tomography Images Using Branched Gold Nanoparticles英文文献资料.docVIP

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Contrast Enhancement of Optical Coherence Tomography Images Using Branched Gold Nanoparticles英文文献资料.doc

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Contrast Enhancement of Optical Coherence Tomography Images Using Branched Gold Nanoparticles英文文献资料

HindawiPublishingCorporation JournalofNanomaterials Volume2012,ArticleID571015,9pages doi:10.1155/2012/571015 ResearchArticle ContrastEnhancementofOpticalCoherenceTomographyImages UsingBranchedGoldNanoparticles Y.PoncedeLeo′n,J.L.Pichardo-Molina,N.Alcal′aOchoa, andD.Luna-Moreno PhotonicsDivision,CentrodeInvestigacionesenOptica,′ A.C.LomadelBosque115,Col.LomasdelCampestre, 37150Le′on,GTO,Mexico CorrespondenceshouldbeaddressedtoJ.L.Pichardo-Molina,jpichardo@cio.mx Received7August2012;Revised29September2012;Accepted12October2012 AcademicEditor:ShuangxiXing Copyright?2012Y.PoncedeLeo′netal. This is an open access article distributed under the Creative Commons Attribution License,whichpermitsunrestricteduse,distribution,andreproductioninanymedium,providedtheoriginalworkisproperly cited. We propose the use of branched gold nanoparticles (B-GNPs) as a contrast agent for optical coherence tomography (OCT) imaging.OurresultsshowthatevenwhenthecentralsourceofourOCT(1325nm)istoofarfromthemaximumpeakofthe plasmon resonance, branched nanoparticles scatter light very e?ciently at this wavelength. B-GNPs were tested as a contrast agentinwaterandagarose-TiO2tissuephantoms;theestimatedincrementsincontrastwere9.19dBand15.07dBforbranched nanoparticlesinwaterwithconcentrationsof2.2×10 NPs/mLand6.6×10 NPs/mL,respectively,whileforagarose-TiO2tissue 9 9 phantomstheestimatedvaluewas3.17dB.TheseresultsshowthepromisingapplicationofB-GNPsasacontrastagentfortissue imagingusingOCT,notonlyforsourcesat1325nmbutalsoatothercentralwavelengthslocatedbetween800and1000nm. 1.Introduction also present, such as second harmonic generation (SHG) [19,20].Additionally,goldNPsarebiocompatibleandnon- toxic,andtheycanbefunctionalizedtotargetspeci?cbio- markersoftissueandcells[21–23]. Nanoparticlesofdi?erentmorphologies,suchasnano- spheres,nanocages,ornanorods,havebeenusedtoincrease thecontrastofOCTimages;however,thereportsshowthat thosegeometriesandsizesdonotsigni?cantlyimprove