自闭症︰新陈代谢、线粒体和微生物组.docxVIP

November 2013, Volume 2, Number 6  HYPERLINK /doi/abs/10.7453/gahmj.2013.088 ? Previous Article?|? HYPERLINK /doi/abs/10.7453/gahmj.2013.092 Next Article ? ORIGINAL ARTICLE Autism: Metabolism, Mitochondria, and the Microbiome 自闭症：新陈代谢、线粒体和微生物组 Autismo: metabolismo, mitocondria y microbioma  HYPERLINK /action/doSearch?Contrib=MacFabe%2C+D Derrick?MacFabe,? HYPERLINK /action/doSearch?Contrib= MD,?Canada  HYPERLINK /action/showMailPage?href=%2Fdoi%2Fabs%2F10.7453%2Fgahmj.2013.089title=Autism%3A+Metabolism%2C+Mitochondria%2C+and+the+Microbiomedoi=10.7453%2Fgahmj.2013.089 ?Share Affiliation:?The Kilee Patchell-Evans Autism Research Group, Departments of Psychology (Neuroscience) and Psychiatry, Division of Developmental Disabilities, Lawson Research Institute, University of Western Ontario, London, Ontario, Canada. Correspondence:? HYPERLINK mailto:dmacfabe@uwo.ca dmacfabe@uwo.ca Citation:?Global Adv Health Med. 2013;2(6):52-66 Disclosure?Dr MacFabe completed the ICMJE Disclosure Form for Potential Conflicts of Interest and had no conflicts related to this work to disclose. ABSTRACT New approaches are needed to examine the diverse symptoms and comorbidities of the growing family of neurodevelopmental disorders known as autism spectrum disorder (ASD). ASD originally was thought to be a static, inheritable neurodevelopmental disorder, and our understanding of it is undergoing a major shift. It is emerging as a dynamic system of metabolic and immune anomalies involving many organ systems, including the brain, and environmental exposure. The initial detailed observation and inquiry of patients with ASD and related conditions and the histories of their caregivers and families have been invaluable. How gastrointestinal (GI) factors are related to ASD is not yet clear. Nevertheless, many patients with ASD have a history of previous antibiotic exposure or hospitalization, GI symptoms, abnormal food cravings, and unique intestinal bacterial populations, which h