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Rapid Development of Th2 Activity During T Cell Priming 外文参考文献
ClinicalDevelopmentalImmunology,March2003,Vol.10(1),pp.1–6
RapidDevelopmentofTh2ActivityDuringTCellPriming
ADAMF.CUNNINGHAMandKAI-MICHAELTOELLNER*
UniversityofBirmingham,MedicalResearchCouncilCentreforImmuneRegulation,BirminghamB152TT,UK
TheparadigmofThelper-1(Th-1)andTh-2cellsdevelopingfromnon-committedna?¨veprecursorsis
?rmlyestablished.Th1cellsarecharacterizedbyIFNgproductionand,inmice,theselectiveswitching
toIgG2a.ConverselyIL-4productionandselectiveswitchingtoIgG1andIgEcharacterizeTh2cells.
AnalysisofTh2inductioninvitroindicatesthatthispolarizationdevelopsgraduallyinTcellsactivated
byan
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