Rapid Development of Th2 Activity During T Cell Priming 外文参考文献.docVIP

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Rapid Development of Th2 Activity During T Cell Priming 外文参考文献.doc

Rapid Development of Th2 Activity During T Cell Priming 外文参考文献

ClinicalDevelopmentalImmunology,March2003,Vol.10(1),pp.1–6 RapidDevelopmentofTh2ActivityDuringTCellPriming ADAMF.CUNNINGHAMandKAI-MICHAELTOELLNER* UniversityofBirmingham,MedicalResearchCouncilCentreforImmuneRegulation,BirminghamB152TT,UK TheparadigmofThelper-1(Th-1)andTh-2cellsdevelopingfromnon-committedna?¨veprecursorsis ?rmlyestablished.Th1cellsarecharacterizedbyIFNgproductionand,inmice,theselectiveswitching toIgG2a.ConverselyIL-4productionandselectiveswitchingtoIgG1andIgEcharacterizeTh2cells. AnalysisofTh2inductioninvitroindicatesthatthispolarizationdevelopsgraduallyinTcellsactivated byan

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