Reductive Evolution in Bacteria Buchnera sp., Rickettsia prowazekii and Mycobacterium leprae 外文参考文献.docVIP

ComparativeandFunctionalGenomics CompFunctGenom2001;2 :44–48. FeaturedOrganism Reductiveevolutioninbacteria:Buchnera sp.,RickettsiaprowazekiiandMycobacterium leprae JoWixon,ManagingEditor J.Wixon,BioinformaticsDivision,HGMP-RC,Hinxton,CambridgeCB101SA,UK Abstract Obligate intracellular bacteria commonly have much reduced genome sizes compared to their nearest free-living relatives. One reason for this is reductive evolution: the loss of genesrenderednon-essentialduetotheintracellularhabitat.Thiscanoccurbecauseofthe presence of orthologous genes in the host, combined with the ability of the b