Cell-mediatedImmunityandAntigenPresentation细胞介导的免疫和抗原呈递.pptVIP

Dental Microbiology #211IMMUNOLOGYLecture 5Cellular Immunity: The functions of T cells Topics The T lymphocyte Structure of the T cell Receptor Fig. 1 Two classes of T lymphocytes CD4 and CD8 act as co-receptors Fig 2 Effector T cells Properties of Th-1 cells Effector function of T lymphocytes Fig. 3 Granuloma Fig 4 Properties of Th-2 cells Effector function of T lymphocytes Fig. 5 T cell help for Ab formation by B cells Fig 6 Properties of CTL Effector function of T lymphocytes Fig. 7 Cytotoxic Molecules of CD8+ T cells Fig 8 One CTL kills multiple targets Fig 9 END * The Ag-specific T cell receptor Distinct populations of T cells The T effector cells- what do they do and how Cell-mediated immunity is operated by T lymphocytes, and by antigen-presenting cells (APC) The T lymphocytes undergo maturation in the thymus from undifferentiated lymphoid progenitors that arrive from the bone marrow. T cells are characterized by the expression of antigen-specific T cell receptors (TCR). T cells produce and express only the cell-bound molecules. The TCR is composed of two polypeptide chains: the (the L chain counterpart) and the $ (the H chain counterpart of Ig). The extracellular portion of each chain has a variable (V) and constant (C) domain. Both chains have carbohydrate moieties (blue hexagons) Each TCR molecule has only one binding site. Following a complex process of maturation in the thymus, T cells separate into two distinct populations: They are called CD4+ and CD8+ T cells. Mature T cells express either the CD4 or the CD8 molecule on their surface but not both, and perform distinct biologic functions. The CD4 and CD8 molecules are called co-receptors because, when the T cell binds the Ag-MHC complex, they interact both with the TCR on the T cell surface and with the MHC on the APC The binding of Ag peptide-MHC complex present on an APC to the TCR starts a chain of intracellular signaling events that results in the activation, proliferation and