A Comparison of Mathematical Models for Polarization of Single Eukaryotic Cells in Response to Guided Cues 英文参考文献.docVIP

Review AComparisonofMathematicalModelsforPolarizationof SingleEukaryoticCellsinResponsetoGuidedCues AlexandraJilkine1*,LeahEdelstein-Keshet2 1GreenComprehensiveCenterforComputationalandSystemsBiology,DepartmentofPharmacology,UniversityofTexasSouthwesternMedicalCenter,Dallas,Texas, UnitedStatesofAmerica,2MathematicsDepartment,UniversityofBritishColumbia,Vancouver,BritishColumbia,Canada circuit, is then dissected into modules, each comprised of a few components. By understanding these modules, and then linking Abstract: Polarization,aprimarystepintheresponseof an individual eukaryotic cell to a spatial stimulus, has attracted numerous theoretical treatments complement- ing experimental studies in a variety of cell types. While these together, we hope to understand the function of the molecular network as a whole [8,9]. In a distinct approach, theorists askew thedetailed network, and look atsimpler models the phenomenon itself is universal, details differ across thathaveanalogouscapabilities(e.g.,symmetrybreaking,response cell types, and across classes of models that have been togradedornoisyinputs,etc.).Here,wesurveylargelymodelsof proposed.Mostmodelsaddresshowsymmetrybreaking thelattertype,andbrieflymentionafewoftheformer. leads to polarization, some in abstract settings, others based on specific biochemistry. Here, we compare polarization in response to a stimulus (e.g., a chemoat- We first summarize collective and universal features of cell polarization.Theseleadtoanumberofimportantquestionsthat tractant) in cells typically used in experiments (yeast, amoebae, leukocytes, keratocytes, fibroblasts, and neu- rons), and, in parallel, responses of several prototypical modelstotypicalstimulationprotocols.Wefindthatthe diversity of cell behaviors is reflected by a diversity of models, and that some, but not all models, can account for amplification of stimulus, maintenance of polarity, adaptation,sensitivitytonewsignals,androbustness. theory has been directed at ans